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base analog
A base analog is chemical that can substitute for a normal nucleobase in nucleic acids.
They are categorized in two separate groups, purine analogues and pyrimidine analogues.
One of the most common base analogs is 5-bromouracil (5BU), the abnormal base found in the mutagenic nucleotide analog BrdU. When a nucleotide containing 5-bromouracil is incorporated into the DNA, it is most likely to pair with adenine; however, it can spontaneously shift into another isomer which pairs with a different nucleobase, guanine. If this happens during DNA replication, a guanine will be inserted as the opposite base analog, and in the next DNA replication, that guanine will pair with a cytosine. This results in a change in one base pair of DNA, specifically a transition mutation.
==See also==
*Antimetabolite
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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